| Bioactivity | Tyrphostin AG1296 is a potent and selective inhibitor of platelet-derived growth factor receptor (PDGFR), with an IC50 of 0.8 μM. Tyrphostin AG1296 inhibits signaling of human PDGF α- and β-receptors as well as of the related stem cell factor receptor (c-Kit). Tyrphostin AG1296 is also a potent inhibitor of FLT3, with an IC50 in the micromolar range[1][2][3]. | ||||||||||||
| Invitro | Tyrphostin AG1296 (0.625-20 μM; 72 h) suppresses viability of PLX4032-resistant melanoma cells[4].Tyrphostin AG1296 (2.5-20 μM; 48 h) induces apoptosis of A375R cells[4].Tyrphostin AG1296 (5 and 20 μM; 2 h) inhibits PDGFR phosphorylation in A375R cells[4].Tyrphostin AG1296 (0.0625-1 μM; 8 h) inhibits migration of A375R cells[4]. Cell Viability Assay[4] Cell Line: | ||||||||||||
| Name | Tyrphostin AG1296 | ||||||||||||
| CAS | 146535-11-7 | ||||||||||||
| Formula | C16H14N2O2 | ||||||||||||
| Molar Mass | 266.29 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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Tyrphostin AG1296
CAS: 146535-11-7 F: C16H14N2O2 W: 266.29
Tyrphostin AG1296 is a potent and selective inhibitor of platelet-derived growth factor receptor (PDGFR), with an IC50 o
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