| Bioactivity | Tyrphostin AG1112 is a potent inhibitors of CK II. Tyrphostin AG1112 inhibits p210bcr-abl tyrosine kinase, with IC50 values of 2, 15, 20 μM in p210bcr-abl, EGFR and PDGFR cells, respectively[1][2]. |
| Invitro | Tyrphostin AG1112 (0-100 μM) dose-dependently induces differentiation also induce specific growth arrest[1]. |
| Name | Tyrphostin AG1112 |
| CAS | 153150-84-6 |
| Formula | C15H10N6 |
| Molar Mass | 274.28 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. T B Kang, et al. Action of 3 tyrphostin derivatives on casein kinase II from rat liver. Zhongguo Yao Li Xue Bao. 1997 Jan;18(1):56-8. [2]. M Anafi, et al. Tyrphostin-induced inhibition of p210bcr-abl tyrosine kinase activity induces K562 to differentiate. Blood. 1993 Dec 15;82(12):3524-9. |
Tyrphostin AG1112
CAS: 153150-84-6 F: C15H10N6 W: 274.28
Tyrphostin AG1112 is a potent inhibitors of CK II. Tyrphostin AG1112 inhibits p210bcr-abl tyrosine kinase, with IC50 val
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