| Bioactivity | Tyrphostin A51 is a potent protein tyrosine kinase (PTK) inhibitor. Tyrphostin A51 inhibits the volume-dependent release of [3H]taurine in a dose-dependent manner. Tyrphostin A51 markedly reduces cellular tyrosyl phosphorylation level. Tyrphostin A51 inhibits both basal and EGF-induced human bone cell proliferation[1][2]. | ||||||||||||
| Name | Tyrphostin A51 | ||||||||||||
| CAS | 126433-07-6 | ||||||||||||
| Formula | C13H8N4O3 | ||||||||||||
| Molar Mass | 268.23 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Alexander A. et al. [3H]taurine andd-[3H]aspartate release from astrocyte cultures are differently regulated by tyrosine kinases. Physiology-cell physiology. 1999, 1226-1230. [2]. Yoon HK, et al. Differential effects of two protein tyrosine kinase inhibitors, tyrphostin and genistein, on human bone cell proliferation as compared with differentiation. Calcif Tissue Int. 1998 Sep;63(3):243-9. |
Tyrphostin A51
CAS: 126433-07-6 F: C13H8N4O3 W: 268.23
Tyrphostin A51 is a potent protein tyrosine kinase (PTK) inhibitor. Tyrphostin A51 inhibits the volume-dependent release
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