| Bioactivity | Tyrphostin 25 (AG82) is a specific inhibitor of the EGFR tyrosine kinase. Tyrphostin 25 is also a GPR35 agonist with an IC50 of 0.94 µM and an EC50 of 5.3 µM[1][2]. |
| Target | EGFR tyrosine kinaseIC50: 0.94 µM (GPR35)EC50: 5.3 µM (GPR35) |
| Name | Tyrphostin 25 |
| CAS | 118409-58-8 |
| Formula | C10H6N2O3 |
| Molar Mass | 202.17 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Klemke RL, et al. Receptor tyrosine kinase signaling required for integrin alpha v beta 5-directed cell motility but not adhesion on vitronectin. J Cell Biol. 1994 Nov;127(3):859-66. [2]. Deng H, et al. Tyrphostin analogs are GPR35 agonists. FEBS Lett. 2011 Jun 23;585(12):1957-62. |
Tyrphostin 25
CAS: 118409-58-8 F: C10H6N2O3 W: 202.17
Tyrphostin 25 (AG82) is a specific inhibitor of the EGFR tyrosine kinase. Tyrphostin 25 is also a GPR35 agonist with an
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