| Bioactivity | Tyrosine kinase-IN-8 (compound 4e) is a BCR‐ABL1 tyrosine kinase inhibitor (TKI). Tyrosine kinase-IN-8 shows anti-proliferative activity against K562 cells, a chronic myeloid leukemia (CML) cell line (CC50=0.8 µM). Tyrosine kinase-IN-8 can be used in the study of chronic leukemia[1]. |
| Invitro | Tyrosine kinase-IN-8 (1 和 10 µM， 48 h) 在 K562 细胞系中表现出良好的抗白血病活性， 但对 WSS-1 细胞的毒性也更大[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Tyrosine kinase-IN-8 相关抗体: Cell Viability Assay[1] Cell Line: |
| Formula | C31H21F2N7O2 |
| Molar Mass | 561.54 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. de Azevedo L D, et al. Spirooxadiazoline‐oxindoles derived from imatinib show antimyeloproliferative potential in K562 cells[J]. Archiv der Pharmazie, 2024: e2400029. |
Tyrosine kinase-IN-8
CAS: F: C31H21F2N7O2 W: 561.54
Tyrosine kinase-IN-8 (compound 4e) is a BCR‐ABL1 tyrosine kinase inhibitor (TKI). Tyrosine kinase-IN-8 shows anti-proli
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