| Bioactivity | Tyr-W-MIF-1 is an opioid tetrapeptide with opiate and antiopiate activity. Tyr-W-MIF-1 can induce analgesia[1][2][5]. |
| Invitro | Tyr-W-MIF-1 (1-10 μM) 抑制 LC 神经元的自发放电[1]。Tyr-W-MIF-1 减弱 Morphine (3 μM) 诱导的 SH-SY5Y 人神经母细胞瘤细胞中 mu 和 delta 受体的下调[4]。Tyr-W-MIF-1 (0.3 μM) 抑制3H-DAMGO (对μ阿片受体有选择性) 与大鼠脑的结合[5]。 |
| In Vivo | Tyr-W-MIF-1 (i.c.v，5 μL, 200 μg) 诱导大鼠镇痛时间延长[2]。Tyr-W-MIF-1 (i.t., 0.75 μg) 诱导镇痛，并被 Naloxone 逆转[3]。 Animal Model: |
| Name | Tyr-W-MIF-1 |
| CAS | 144450-13-5 |
| Shortening | YPWG-NH2 |
| Formula | C27H32N6O5 |
| Molar Mass | 520.58 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yang YR, et L. Opioid and antiopioid actions of Tyr-MIF-1, Tyr-W-MIF-1 and hemorphin-4 on rat locus coeruleus neurons: intracellular recording in vitro. Chin J Physiol. 1997 Sep 30;40(3):131-5. [2]. Gergen KA, et al. Expression of the FOS proto-oncogene protein in brain after ICV administration of Tyr-W-MIF-1 (Tyr-Pro-Trp-Gly-NH2). Peptides. 1994;15(8):1505-11. [3]. Gergen KA, et al. Intrathecal Tyr-W-MIF-1 produces potent, naloxone-reversible analgesia modulated by alpha 2-adrenoceptors. Eur J Pharmacol. 1996 Mar 18;298(3):235-9. [4]. Harrison LM, et al. Tyr-W-MIF-1 attenuates down-regulation of opiate receptors in SH-SY5Y human neuroblastoma cells. J Pharmacol Exp Ther. 1998 Feb;284(2):611-7. [5]. Erchegyi J, et al. Isolation of a novel tetrapeptide with opiate and antiopiate activity from human brain cortex: Tyr-Pro-Trp-Gly-NH2 (Tyr-W-MIF-1). Peptides. 1992 Jul-Aug;13(4):623-31. |