| Bioactivity | Tyk2-IN-22 (Compound A8) is a selective inhibitor for tyrosine kinase 2 (Tyk2), that it inhibits Tyk2, JAK1, and JAK3 with IC50s of 9.7, 148.6, and 883.3 nM, respectively. Tyk2-IN-22 inhibits the downstream STAT5 phosphorylation[1]. |
| CAS | 933667-23-3 |
| Formula | C16H16ClN5O2 |
| Molar Mass | 345.78 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Istanbullu H, et al. Discovery of selective TYK2 inhibitors: Design, synthesis, in vitro and in silico studies of promising hits with triazolopyrimidinone scaffold[J]. Bioorganic Chemistry, 2024, 148: 107430. |
Tyk2-IN-22
CAS: 933667-23-3 F: C16H16ClN5O2 W: 345.78
Tyk2-IN-22 (Compound A8) is a selective inhibitor for tyrosine kinase 2 (Tyk2), that it inhibits Tyk2, JAK1, and JAK3 wi
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