| Bioactivity | TyK2-IN-21-d3 (Compound 3c) is the orally active prodrug of the tyrosine kinase 2. TyK2-IN-21-d3 exhibits good chemical stability in aqueous system under different pHs. TyK2-IN-21-d3 alleviates the effect of gastric acid changes on drug absorption and improve the drug bioavailability in rat model[1]. |
| CAS | 2583719-08-6 |
| Formula | C21H22D3N8O7P |
| Molar Mass | 535.46 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. A M Subbaiah M, et al., Prodrug Strategy to Address Impaired Oral Absorption of a Weakly Basic TYK2 Inhibitor Caused by a Gastric Acid-Reducing Agent. J Med Chem. 2024 Nov 28;67(22):20664-20681. |
TyK2-IN-21-d3
CAS: 2583719-08-6 F: C21H22D3N8O7P W: 535.46
TyK2-IN-21-d3 (Compound 3c) is the orally active prodrug of the tyrosine kinase 2. TyK2-IN-21-d3 exhibits good chemical
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