| Bioactivity | Tumulosic acid, a triterpenoid, inhibits KLK5 protease activity (IC50= 14.84 μM). Tumulosic acid suppresses the proteolytic processing of LL-37 in keratinocytes at ≤10 μM[1]. |
| Invitro | Tumulosic acid displays dose-dependent anti-KLK5 activity (IC50=19.3 μM)[1].Tumulosic acid decreases in LL-37 production in human keratinocytes[1]. Tumulosic acid shows IC50 values of 14.84 and 10.48 μM against KLK5 and trypsin proteases, while it exhibited a weak inhibitory effect on KLK7 and chymotrypsin C proteases (19.5% and 4.0%, respectively, at 100 μM)[1]. Western Blot Analysis[1] Cell Line: |
| Name | Tumulosic acid |
| CAS | 508-24-7 |
| Formula | C31H50O4 |
| Molar Mass | 486.73 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |