| Bioactivity | Tubulysin D is one of the most potent derivatives among the tubulysins isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis. Tubulysin D is a novel tetrapeptide that displays potent antitumor activity and leads to cell cycle arrest and apoptosis by inhibiting tubulin polymerization with an IC50 of 1.7 μM[1]. Tubulysin displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the lower nanomolar range[2]. |
| Invitro | Tubulysin D has IC50s of 4.7 pM, 3.1 pM, 670 pM and 13 pM for HL60, HCT116, MCF7, A549 cell lines antiproliferative activity, respectively[1]. |
| Name | Tubulysin D |
| CAS | 309935-57-7 |
| Formula | C43H65N5O9S |
| Molar Mass | 828.07 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Tubulysin D
CAS: 309935-57-7 F: C43H65N5O9S W: 828.07
Tubulysin D is one of the most potent derivatives among the tubulysins isolated from the myxobacterial species Archangiu
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