| Bioactivity | Tubulin/PARP-IN-1 (compound 14) is a dual PARP-tubulin inhibitor with activity against endometrial cancer. Tubulin/PARP-IN-1 inhibits PARP and tubulin with IC50s of 74 nM (PARP1), 109 nM (PARP2), and 1.4 μM (Microtubule/Tubulin), respectively. Tubulin/PARP-IN-1 can induce apoptosis and autophagy and cause cell cycle arrest in the G2/M phase[1]. |
| Target | IC50: 74 nM (PARP1), 109 nM (PARP2), 1.4 μM (Microtubule/Tubulin) |
| Name | Tubulin/PARP-IN-1 |
| Formula | C19H13FO3 |
| Molar Mass | 308.30 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Sharma S et al. Flavone-based dual PARP-Tubulin inhibitor manifesting efficacy against endometrial cancer. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2276665. |