| Bioactivity | Tubulin/HDAC-IN-3 (compound 12a) is a potent tubulin/HDAC dual inhibitor. Tubulin/HDAC-IN-3 effectively disrupts tubulin polymerization (IC50: 5.4 μM). Tubulin/HDAC-IN-3 exhibits potent HDAC1/8 inhibitory activities, with IC50 values of 0.155 and 0.177 μM, respectively. Tubulin/HDAC-IN-3 works through blocking cellular cycle, inducing apoptosis and inhibiting colony formation[1]. |
| Invitro | Tubulin/HDAC-IN-3 (compound 12a) 在体外对四种肿瘤细胞系 (BE-(2)-C、A549、U87MG 和 HCT116) 显示出抗增殖活性，IC50 值为 0.017 分别为 ±0.002、0.053±0.003、0.056±0.005 和 0.051±0.003 μM[1]。 0 --> Tubulin/HDAC-IN-3 相关抗体: |
| In Vivo | Tubulin/HDAC-IN-3 (compound 12a) (25 mg/kg，每三天腹腔注射)在小鼠中表现出显着的抗肿瘤功效[1]。 |
| Name | Tubulin/HDAC-IN-3 |
| Formula | C28H28N2O10 |
| Molar Mass | 552.53 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Tang H, et al. Discovery of chiral 1,4-diarylazetidin-2-one-based hydroxamic acid derivatives as novel tubulin polymerization inhibitors with histone deacetylase inhibitory activity. Bioorg Med Chem. 2023 Sep 7;92:117437. |