| Bioactivity | Tubulin polymerization-IN-77 (Compound 15c) is a tubulin polymerization inhibitor that exerts anti-glioblastoma activity by inhibiting tubulin polymerization. Tubulin polymerization-IN-77 demonstrates significant blood-brain barrier permeability, effectively inducing G2/M phase arrest and triggering apoptosis in GBM cells, while also significantly inhibiting tumor cell migration[1]. |
| CAS | 3023350-32-2 |
| Formula | C22H19BrF3NO7 |
| Molar Mass | 546.29 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Cui G, et al. Discovery of N-Trifluoromethylated Noscapines as Novel and Potent Agents for the Treatment of Glioblastoma. J Med Chem. 2025 Jan 9;68(1):247-260. |
Tubulin polymerization-IN-77
CAS: 3023350-32-2 F: C22H19BrF3NO7 W: 546.29
Tubulin polymerization-IN-77 (Compound 15c) is a tubulin polymerization inhibitor that exerts anti-glioblastoma activity
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