| Bioactivity | Tubulin polymerization-IN-71 (Compound 4k) is an inhibitor for tubulin polymerization with an IC50 of 3.06 μM. Tubulin polymerization-IN-71 inhibits the proliferation of cancer cell MG-63 and U2OS with IC50 of 0.08-0.14 μM. Tubulin polymerization-IN-71 arrests the cell cycle at G2/M phase, and induces apoptosis in MG-63[1]. |
| Formula | C25H24FNO8 |
| Molar Mass | 485.46 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Chen Z, et al., Design and evaluation of novel N-substituent diphenylamine derivatives as tubulin colchicine binding site inhibitors. Bioorg Med Chem Lett. 2025 Jan 1;115:130031. |
Tubulin polymerization-IN-71
CAS: F: C25H24FNO8 W: 485.46
Tubulin polymerization-IN-71 (Compound 4k) is an inhibitor for tubulin polymerization with an IC50 of 3.06 μM. Tubulin
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