Tubulin polymerization-IN-65_product_DataBase

Bioactivity	Tubulin polymerization-IN-65 is a tubulin polymerisation inhibitor with a broad spectrum cytotoxic. Tubulin polymerization-IN-65 induces G2 + M cell cycle arrest[1].
Invitro	Tubulin polymerization-IN-65（化合物 64；5 μM；24 小时）诱导 G2 + M 细胞周期停滞[1]。 Tubulin polymerization-IN-65 (72 小时) 抑制 HT29、U87、MC-7、A2780、H460、A431、Du145、BE2-C、SJ-G2、MIA、MCF10A 的细胞生长，GI50 分别为 0.26 μM、1.4 μM、0.35 μM、0.33 μM、0.42 μM、0.33 μM、0.90 μM、0.31 μM、0.79 μM、0.37 μM 和 0.56 μM[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Tubulin polymerization-IN-65 相关抗体: Cell Cycle Analysis[1] Cell Line:
Formula	C17H14N2O2
Molar Mass	278.31
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Nicholas S O'Brien, et al. 2,3-Dihydroquinazolin-4(1 H)-ones and quinazolin-4(3 H)-ones as broad-spectrum cytotoxic agents and their impact on tubulin polymerisation. RSC Med Chem. 2024 Mar 6;15(5):1686-1708.

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