Tubulin polymerization-IN-61

CAS: 2758114-60-0 F: C22H21N3O5 W: 407.42

Tubulin polymerization-IN-61 (Compound 9a) is a tubulin polymerization inhibitor. Tubulin polymerization-IN-61 destroys

Contact QiTai

This product is for research use only, not for human use. We do not sell to patients.

Bioactivity	Tubulin polymerization-IN-61 (Compound 9a) is a tubulin polymerization inhibitor. Tubulin polymerization-IN-61 destroys the microtubule skeleton, blocks the cell cycle in G2/M phase, induces Apoptosis, and inhibits cancer cell migration and colony formation. Tubulin polymerization-IN-61 shows antitumor activity in vivo against 4T1 xenograft model[1].
Invitro	Tubulin polymerization-IN-61 对三种人类癌细胞系 (MCF-7、SGC-7901 和 A549) 具有抗增殖活性，IC50 值范围为 14 至 45 nM[1]。Tubulin polymerization-IN-61 (20-60 nM,24 h) 将 MCF-7 细胞 G2/M 周期比例从 14% 增加至 50%，诱导细胞凋亡，并抑制 MCF-7 细胞迁移和集落形成[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Tubulin polymerization-IN-61 相关抗体:
In Vivo	Tubulin polymerization-IN-61 (5 或 15 mg/kg，静脉注射，每两天一次，持续 2 周) 在 BALB/c 小鼠 4T1 异种移植肿瘤模型中显示出抗肿瘤作用，且毒性可忽略不计[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS	2758114-60-0
Formula	C22H21N3O5
Molar Mass	407.42
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Mingxin Huang, et al. Structure-based approaches for the design of 6-aryl-1-(3,4,5-trimethoxyphenyl)-1H-benzo[d][1,2,3]triazoles as tubulin polymerization inhibitors. European Journal of Medicinal Chemistry. Volume 269, 5 April 2024, 116309.

Antitumor agent-144