Tubulin polymerization-IN-40_product_DataBase

Bioactivity	Tubulin polymerization-IN-40 is a potent acridane-based tubulin polymerization inhibitor with an IC50 of 1.5 μM. Tubulin polymerization-IN-40 arrests cancer cells at the G2/M phase and induces the apoptosis. Tubulin polymerization-IN-40 has anti-cancer activity and immunopotentiating effects[1].
Invitro	Tubulin polymerization-IN-40 (化合物 NT-6) 对四种癌细胞系 (HCT-116, B16-F10, HeLa, HepG2) 显示出显着的抗增殖效力，平均 IC50 为 30 nM[1]。Tubulin polymerization-IN-40 (10, 25, 50 nM; 48 小时) 可有效诱导 B16-F10 细胞凋亡[1]。Tubulin polymerization-IN-40 (10, 25, 50 nM; 24 小时) 在 G2/M 期阻滞 B16-F10 细胞[1]。Tubulin polymerization-IN-40 (25, 50, 100 nM; 24 小时) 在 50 nM 时显着抑制 B16-F10 集落的形成，并且在处理 24 小时后抑制率接近 100%[1]。 Tubulin polymerization-IN-40 (10, 25, 50 nM; 24 小时) 可以剂量依赖性方式有效抑制 B16-F10 细胞的迁移[1]。 Apoptosis Analysis[1] Cell Line:
Name	Tubulin polymerization-IN-40
Formula	C24H22FNO5
Molar Mass	423.43
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.

PeptideDB