Tubulin polymerization-IN-39_product_DataBase

Bioactivity	Tubulin polymerization-IN-39 is a tubulin polymerization inhibitor (IC50: 4.9 μM). Tubulin polymerization-IN-39 occupies the colchicine-binding site. Tubulin polymerization-IN-39 inhibits cancer cell proliferation[1].
Invitro	Tubulin polymerization-IN-39 (compound 4k) 对 HeLa、HCT116、A549 和 T47D 细胞具有抗增殖活性，IC50 值分别为 0.31、1.28、3.99 和 10.32 μM[ 1].Tubulin polymerization-IN-39 (0.15-0.6 μM, 24 h) 增加 G2/M 期 HeLa 细胞的百分比[1]。Tubulin polymerization-IN-39 (0.15-0.6 μM, 24 h) 通过增加裂解的 PARP 诱导 HeLa 细胞凋亡[1] 。Tubulin polymerization-IN-39 (0.2-0.8 μM, 24 h) 抑制 HUVEC 的迁移[1]。Tubulin polymerization-IN-39 (10 μM) 抑制 78% 的微管蛋白聚合[1]。 Cell Viability Assay[1] Cell Line:
Name	Tubulin polymerization-IN-39
Formula	C21H21N5O5
Molar Mass	423.42
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Chen L, et al. Rational design, synthesis and biological evaluation of novel 2-(substituted amino)-[1,2,4]triazolo[1,5-a]pyrimidines as novel tubulin polymerization inhibitors. Eur J Med Chem. 2022 Dec 15;244:114864.

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