| Bioactivity | Tubulin inhibitor 47 (compound C11) is a potent tubulin inhibitor. Tubulin inhibitor 47 induces apoptosis and cell cycle arrest at the M phase. Tubulin inhibitor 47 shows anti-tumor activity[1]. |
| Invitro | Tubulin inhibitor 47 (compound C11) 靶向微管蛋白的秋水仙碱位点以抑制其聚合[1]。Tubulin inhibitor 47 (0, 2, 4, 6, 8, 10 nM) 诱导细胞周期停滞在 M 期[1]。Tubulin inhibitor 47 (0, 5, 10, 20 nM) 以剂量依赖性方式增加 KYSE30 细胞中 p-Histone H3 的表达[1]。Tubulin inhibitor 47 (0, 5, 10, 20 nM; 48 h) 以剂量依赖性方式诱导细胞凋亡[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Tubulin inhibitor 47 相关抗体: Cell Proliferation Assay[1] Cell Line: |
| In Vivo | Tubulin inhibitor 47 (6, 12 mg/kg; i.p.; daily for 15 days) 表现出剂量依赖性抗肿瘤活性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| Formula | C20H16N2O2 |
| Molar Mass | 316.35 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Jia M, et al. Synthesis and biological evaluation of 4-phenyl-5-quinolinyl substituted isoxazole analogues as potent cytotoxic and tubulin polymerization inhibitors against ESCC. Eur J Med Chem. 2024 Jun 18;275:116611. |