| Bioactivity | Tubulin inhibitor 40 (compound 45) is a tubulin inhibitor with IC50 of 1.2 μM. Tubulin inhibitor 40 shows selective cytotoxicity towards cancer cells. Tubulin inhibitor 40 processes antitumor activity [1]. |
| Target | 0.005 μM (Tubulin, A549), 0.008 μM (Tubulin, VA13), 0.009 μM (Tubulin, MCF7’), 0.008 μM (Tubulin, HEK293T) |
| Invitro | Tubulin inhibitor 40 对 A549，VA13，MCF7’ 和 HEK293T 细胞系具有细胞毒性，IC50 值分别为 0.005 μM，0.008 μM，0.009 μM 和 0.008 μM[1]。 Tubulin inhibitor 40 抑制微管蛋白（tubulin）聚合，IC50 值是 1.2 μM [1]。Tubulin inhibitor 40 （1-25 μM, 24 h）可引起 A549 中细胞形态和微管蛋白聚合的变化[1]。 0 --> Tubulin inhibitor 40 相关抗体: Cell Cytotoxicity Assay[1] Cell Line: |
| In Vivo | Tubulin inhibitor 40（静脉注射，20 mg/kg，5 天） 具有抗肿瘤活性[1]。 Animal Model: |
| Name | Tubulin inhibitor 40 |
| Formula | C19H20N2O5 |
| Molar Mass | 356.37 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Georgy L et al., 3,4-Diarylisoxazoles─Analogues of Combretastatin A-4: Design, Synthesis, and Biological Evaluation In Vitro and In Vivo. ACS Pharmacology & Translational Science Article ASAP, January 16, 2024 |