| Bioactivity | Tubulin inhibitor 33, a tubulin polymerization inhibitor, inhibits tubulin polymerization in a dose-dependent manner with an IC50 of 9.05 μM. Tubulin inhibitor 33 has antitumor effects and induces cell apoptosis that can be used for antitumor research[1]. |
| Target | IC50: 9.05 μM (tubulin) |
| Invitro | Tubulin inhibitor 33 (Compound 3a) (0-5 nΜ；24-48 小时) 抑制肿瘤细胞 HepG-2 的增殖、迁移和集落形成，诱导 G2/M 细胞周期阻滞和细胞凋亡[1]。[1]。 Cell Proliferation Assay[1] Cell Line: |
| In Vivo | Tubulin inhibitor 33 (Compound 3a) (5 mg/kg；每天腹腔注射，持续 14 天) 显著抑制黑色素瘤肿瘤生长，TGI 为 62.96%[1]。 Animal Model: |
| Name | Tubulin inhibitor 33 |
| Formula | C24H22N4O3 |
| Molar Mass | 414.46 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ren Y, et.al. X-ray Crystal Structure-Guided Discovery of Novel Indole Analogues as Colchicine-Binding Site Tubulin Inhibitors with Immune-Potentiating and Antitumor Effects against Melanoma. J Med Chem. 2023 May 25;66(10):6697-6714. |