| Bioactivity | Tubulin inhibitor 32 is a potent and orally active tubulin inhibitor. Tubulin inhibitor 32 shows anti-proliferative activity and inhibits microtubule polymerization. Tubulin inhibitor 32 induces Apoptosis and cell cycle arrest at G2/M phase. Tubulin inhibitor 32 shows anti-tumor activity[1]. |
| Invitro | Tubulin inhibitor 32 (compound 6y) (0-2 µM; 24 h) 以剂量依赖性方式抑制 HCT-116 细胞中集落的形成[1]。Tubulin inhibitor 32 (0-100 µM; 24 h) 抑制微管聚合，IC50 值为 8.4 µM[1]。Tubulin inhibitor 32 (0-2 µM; 24, 48 h) 诱导细胞凋亡和细胞周期停滞在 G2/M 期[1]。Tubulin inhibitor 32 在人肝微粒体和大鼠肝微粒体中表现出代谢稳定性，T1/2 值分别为 106.2，6.9 min[1]。 Cell Proliferation Assay[1] Cell Line: |
| In Vivo | Tubulin inhibitor 32 (50、100 mg/kg；口服；每日一次，持续 20 天) 在小鼠体内显示出抗肿瘤活性[1]。 Animal Model: |
| Name | Tubulin inhibitor 32 |
| Formula | C18H19N3O3 |
| Molar Mass | 325.36 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Li G, et al. Design, synthesis, and biological evaluation of diaryl heterocyclic derivatives targeting tubulin polymerization with potent anticancer activities. Eur J Med Chem. 2023 Apr 5;252:115284. |