| Bioactivity | Trypanothione synthetase-IN-3 is a noncompetitive mixed hyperbolic Trypanothione synthetase (TryS) inhibitor (Ki: 0.8 μM). Trypanothione synthetase-IN-3 can be used in the study of parasites, such as L. infantum[1]. |
| Target | Trypanothione synthetase (TryS) |
| Invitro | Trypanothione synthetase-IN-3 (30 min) displays noncompetitive inhibitory behavior against Li TryS with IC50 values of 2 μM -5.6 μM (determined by various substrates)[1].Trypanothione synthetase-IN-3 (24 h) inhibits proliferation of L. infantum axenic amastigotes with an EC50 value of 43.7 μM[1]. |
| Name | Trypanothione synthetase-IN-3 |
| CAS | 1314875-96-1 |
| Formula | C68H54O43 |
| Molar Mass | 1559.13 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Mercedes Alcón-Calderón, et al. Identification of L. infantum trypanothione synthetase inhibitors with leishmanicidal activity from a (non-biased) in-house chemical library. European Journal of Medicinal Chemistry, 2022, 114675. |
Trypanothione synthetase-IN-3
CAS: 1314875-96-1 F: C68H54O43 W: 1559.13
Trypanothione synthetase-IN-3 is a noncompetitive mixed hyperbolic Trypanothione synthetase (TryS) inhibitor (Ki: 0.8 μ
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.