| Bioactivity | Trypanothione synthetase-IN-1 (Compound 1) is a competitive Leishmania infantum trypanothione synthetase (TryS) inhibitor with an IC50 of 14.8 μM when triamine spermidine is as polyamine S[1]. |
| Target | IC50: 14.8 μM (LiTryS, triamine spermidine as polyamine S), 16.2 μM (LiTryS, glutathionylspermidine as polyamine S) |
| Invitro | Trypanothione synthetase-IN-1 (Compound 1) (0-75 μM; 24 or 72 h) shows leishmanicidal activity with cytotoxicity[1].Trypanothione synthetase-IN-1 competes with ATP and the polyamine substrate for binding to LiTryS[1]. Cell Cytotoxicity Assay[1] Cell Line: |
| Name | Trypanothione synthetase-IN-1 |
| CAS | 2355349-41-4 |
| Formula | C40H38F3N7O5S |
| Molar Mass | 785.83 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Alcón-Calderón M, et al. Identification of L. infantum trypanothione synthetase inhibitors with leishmanicidal activity from a (non-biased) in-house chemical library. European Journal of Medicinal Chemistry, 2022: 114675. |
Trypanothione synthetase-IN-1
CAS: 2355349-41-4 F: C40H38F3N7O5S W: 785.83
Trypanothione synthetase-IN-1 (Compound 1) is a competitive Leishmania infantum trypanothione synthetase (TryS) inhibito
Data collection：peptidedb@qq.com
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