| Bioactivity | TrxR-IN-7 (14f) is a potent thioredoxin reductase (TrxR) inhibitor with an IC50 value of 3.5 µM. TrxR-IN-7 shows antiproliferative activity. TrxR-IN-7 induces apoptosis and ROS generation[1]. |
| In Vivo | IC50: 3.5 µM (TrxR)[1] MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| Formula | C22H21NO3 |
| Molar Mass | 347.41 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Huang B, et al. Synthesis and discovery of simplified pleurotin analogs bearing tricyclic core as novel thioredoxin reductase inhibitors. Eur J Med Chem. 2025 Jan 6;285:117242 |