| Bioactivity | Truncated ADR58 is obtained by truncating full-length ADR58 from 71 bases to 31 bases. Truncated ADR58 retains similar functional activity to full-length ADR58, and can be used as a highly potent and selective human oncostatin M (OSM) antagonist that prevent the binding of OSM to the gp130 receptor and specifically antagonize OSM-mediated signaling. Truncated ADR58 can be used in the research of rheumatoid arthritis related diseases[1]. |
| Invitro | Truncated ADR58 表现出与全长 ADR58 相似的活性，在 HEPG2 细胞实验中 IC50为350 nM，在 OSM-gp130 ELISA中 IC50为0.3 μm[1]。 |
| Name | Truncated ADR58 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. A Rhodes, et al. The generation and characterization of antagonist RNA aptamers to human oncostatin M. J Biol Chem. 2000 Sep 15;275(37):28555-61. |