| Bioactivity | TrkA-IN-3 is a potent, subselective and allosteric TrkA inhibitor, with an IC50 of 22.4 nM. TrkA-IN-3 shows more than 8000-fold selectivity for TrkA over TrkB and TrkC. TrkA-IN-3 can be used for the research of pain[1]. |
| Invitro | TrkA-IN-3 (化合物 5) 在浓度为 1 μM 和 0.1 μM 时对 TrkA 的抑制率分别为 73.9% 和 64.8%[1]。 |
| Name | TrkA-IN-3 |
| Formula | C24H17F3N4O3 |
| Molar Mass | 466.41 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Tang S, et, al. Design, development and evaluation of a prodrug-type TrkA-selective inhibitor with antinociceptive effects in vivo. Eur J Med Chem. 2023 Jan 5;245(Pt 2):114901. |