| Bioactivity | Triptohypol C, a Tripterin (HY-13067) derivative, is a potent Nur77-targeting anti-inflammatory agent with an Kd value of 0.87 μM. Triptohypol C inhibits inflammatory response by promoting the interactions of Nur77 with TRAF2 and p62/SQSTM1[1]. |
| Target | Kd: 0.87 μM (Nur77) |
| Invitro | Triptohypol C (compound 3a) (2 μM; 1 h) strongly antagonize the effect of TNFα on inducing IκBα degradation, and inhibits inflammatory response by promoting the interactions of Nur77 with TRAF2 and p62/SQSTM1[1].Triptohypol C (2 μM; 10 h) cause 3.12% apoptosis in HepG2 cells, which is less toxic than Tripterin[1]. Western Blot Analysis[1] Cell Line: |
| In Vivo | Caused 3.12% apoptosis in cells, which was less cytotoxic than Tripterin (>10%). Animal Model: |
| Name | Triptohypol C |
| CAS | 193957-88-9 |
| Formula | C29H40O4 |
| Molar Mass | 452.63 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Chen Z, et al. SAR study of celastrol analogs targeting Nur77-mediated inflammatory pathway. Eur J Med Chem. 2019 Sep 1;177:171-187. |
Triptohypol C
CAS: 193957-88-9 F: C29H40O4 W: 452.63
Triptohypol C, a Tripterin (HY-13067) derivative, is a potent Nur77-targeting anti-inflammatory agent with an Kd value o
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