| Bioactivity | Trigonelline chloride, an alkaloid with potential antidiabetic activity, is present in considerable amounts in Leonurus artemisia. Trigonelline chloride has anti-HSV-1 , antibacterial, and antifungal activities. |
| Invitro | It is found that Trigonelline chloride (TG) significantly rescues the morphology of the H9c2 cells. Treatment of cells with Trigonelline chloride attenuates H2O2 induced cell deaths and improves the antioxidant activity. In addition, Trigonelline chloride regulates the apoptotic gene caspase-3, caspase-9 and anti-apoptotic gene Bcl-2, Bcl-XL during H2O2 induced oxidative stress in H9c2 cells. For evident, flow cytometer results also confirm that Trigonelline chloride significantly reduces the H2O2 induced necrosis and apoptosis in H9c2 cells. However, further increment of Trigonelline chloride concentration against H2O2 can induce the necrosis and apoptosis along with H2O2[1]. |
| Name | Trigonelline chloride |
| CAS | 6138-41-6 |
| Formula | C7H8ClNO2 |
| Molar Mass | 173.60 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |