Trichostatin C_product_DataBase

Bioactivity	Trichostatin C is an inhibitor for histone deacetylase (HDAC), induces apoptosis and arrests cell cycle at G2/M phase, and exhibits anticancer activity against lung cancer and urothelial bladder cancer[1]. Trichostatin C induces differentation of Friend leukemic cells[2]. Trichostatin C exhibits antifungal activity[3].
Invitro	Trichostatin C (0-100 μM) 对 HDAC1 和 HDAC6 表现出抑制活性，抑制癌细胞 A549、J82 和 SK-BR-3 的增殖，IC 50 分别为 6.24，4.16 和 0.6 μM[1]。Trichostatin C (0-10 μM) 通过激活 caspase 3 和 caspase 7 诱导 J82 细胞凋亡 (apoptosis)[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Trichostatin C 相关抗体: Cell Proliferation Assay[1] Cell Line:
CAS	68676-88-0
Formula	C23H32N2O8
Molar Mass	464.51
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Wang C, et al., Trichostatin C Synergistically Interacts with DNMT Inhibitor to Induce Antineoplastic Effect via Inhibition of Axl in Bladder and Lung Cancer Cells[J]. Pharmaceuticals, 2024, 17(4): 425. [2]. Yoshida M, et al., Trichostatin C, a new inducer of differentiation of Friend leukemic cells[J]. Agricultural and biological chemistry, 1985, 49(2): 563-565. [3]. Tsuji N, et al., a glucopyranosyl hydroxamate. J Antibiot (Tokyo). 1978 Oct;31(10):939-44.

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