Treprostinil-d9_product_DataBase

CAS: 2747918-14-3 F: C23H25D9O5 W: 399.57

Treprostinil-d9 (UT-15-d9) is the deuterium-labeled Treprostinil (HY-100441). Treprostinil (UT-15) is a potent DP1 and E

This product is for research use only, not for human use. We do not sell to patients.

Bioactivity	Treprostinil-d9 (UT-15-d9) is the deuterium-labeled Treprostinil (HY-100441)[1]. Treprostinil (UT-15) is a potent DP1 and EP2 agonist with EC50 values of 0.6±0.1 and 6.2±1.2 nM, respectively.
Target	EC50: 0.6±0.1 nM (DP1), 6.2±1.2 nM (EP2)
Invitro	氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。
Name	Treprostinil-d9
CAS	2747918-14-3
Formula	C23H25D9O5
Molar Mass	399.57
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

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