Transthyretin-IN-3_product_DataBase

Bioactivity	Transthyretin-IN-3 (compound 6) is a designed benzofuran analogue. Transthyretin-IN-3 selectively binds to plasma transthyretin(TTR) to inhibit Amyloid aggregation(IC50 = 5.0 ± 0.2 μM). Transthyretin-IN-3 can bind to TTR's thyroxine binding site specifically by carrying chlorine substituents at specific locations in its structure. This binding can prevent TTR tetramers from dissociating into unstable monomers[1].
In Vivo	Transthyretin-IN-3 ( 0.1 mg/kg， iv； 0.1 mg/kg， po； 8 h) 的口服生物利用度 (BA) 为 66.8 %，与目前的有效治疗药物效果相当[1]。Pharmacokinetic Analysis in SD rats[1]药代动力学分析[1]Route
CAS	3008535-20-1
Formula	C17H11ClI2O3
Molar Mass	552.53
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Mizuguchi, Mineyuki, et al. "Development of Benziodarone Analogues with Enhanced Potency for Selective Binding to Transthyretin in Human Plasma." Journal of Medicinal Chemistry (2024).

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