| Bioactivity | Topsalysin (PRX-302; PRX302; PSA-PAH1) is a PSA-activated protoxin, a pore-forming protein (synthetic proaerolysin) fusion protein with human prostate-specific antigen. Topsalysin has tumor suppression effect in mice modle[1]. |
| Invitro | Topsalysin (19 pM-10 nM; 48 小时) 对 LNCaP, PC3, DU145 和 TSU 细胞显示前列腺特异性抗原 (PSA) 依赖性毒性[1]。 |
| In Vivo | Topsalysin (肿瘤内注射; 1-10μg /鼠标; 单次剂量) 抑制小鼠的肿瘤生长[1]。Topsalysin (0.35、4.1、25.8 μg/kg, 25 μL; 腹腔注射; 单剂量) 可杀死食蟹猴前列腺注射部位高达 50% 的细胞[1]。 Animal Model: |
| Name | Topsalysin |
| CAS | 917121-25-6 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Williams SA, et al. A prostate-specific antigen-activated channel-forming toxin as therapy for prostatic disease. J Natl Cancer Inst. 2007 Mar 7;99(5):376-85. |