Topoisomerase IIα-IN-4_product_DataBase

Bioactivity	Topoisomerase IIα-IN-4 (F2) is a non-intercalative ATP-competitive human DNA topoisomerase II inhibitor with an IC50 value of 3.8 and 10.1 μM for TopoIIα and TopoIIβ, respectively. Topoisomerase IIα-IN-4 shows potent potency in apoptosis induction and cell cycle arrest in HepG2 cells. Topoisomerase IIα-IN-4 exhibits strong antitumor activities against human cancer cell lines, it can be used for the research of cancer[1].
Invitro	Topoisomerase IIα-IN-4 (0-50 μM; 72 h) shows antiproliferative activities against cancer cells[1]. Topoisomerase IIα-IN-4 shows high inhibitory activity and subtypeselectivity against TopoIIα and β with IC50s of 3.8 and 10.1 μM, respectively[1].Topoisomerase IIα-IN-4 (0.3 μM; 4 h) is a non-intercalative TopoIIα catalytic inhibitor[1].Topoisomerase IIα-IN-4 (0.5-1 μM; 48 h) induces cell apoptosis[1].Topoisomerase IIα-IN-4 (0.5-1 μM; 24 h) induces cell-cycle arrest[1]. Cell Proliferation Assay[1] Cell Line:
Name	Topoisomerase IIα-IN-4
Formula	C25H21NO2
Molar Mass	367.44
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.

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