| Bioactivity | Topoisomerase IIα-IN-3 (Compound 12c) is a DNA intercalative topoisomerase-IIα inhibitor. Topoisomerase IIα-IN-3 arrests cell cycle at the G0/G1 phase and induces apoptosis[1]. |
| Invitro | Topoisomerase IIα-IN-3 (Compound 12c) shows cytotoxic potential with IC50 values of 2.82 ± 0.10, 3.28 ± 0.43, 4.09 ± 0.59, 4.78 ± 1.29, 3.83 ± 0.9,4 3.18 ± 0.49 and 71.25 ± 7.95 μM against A549, MDA-MB-231, BT-474, HCT-116, HL-60, THP-1 and BEAS-2B cells, respectively[1]. |
| Name | Topoisomerase IIα-IN-3 |
| CAS | 2538528-11-7 |
| Formula | C29H20N6O2S |
| Molar Mass | 516.57 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Topoisomerase IIα-IN-3
CAS: 2538528-11-7 F: C29H20N6O2S W: 516.57
Topoisomerase IIα-IN-3 (Compound 12c) is a DNA intercalative topoisomerase-IIα inhibitor. Topoisomerase IIα-IN-3 arre
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