| Bioactivity | Topoisomerase II inhibitor 14 (compound 2f) is a potent inhibtor of Topoisomerase II, with anticancer activity. Topoisomerase II inhibitor 14 induces apoptosis, and arrests cell cycle at S phase. Topoisomerase II inhibitor 14 exhibits antioxidant effect and decreases the level of GSH, MDA, and NO[1]. |
| In Vivo | Topoisomerase II inhibitor 14 (compound 2f) |
| Name | Topoisomerase II inhibitor 14 |
| CAS | 305343-00-4 |
| Formula | C15H11Cl2N5 |
| Molar Mass | 332.19 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Al-Karmalawy AA, et al. Novel fused imidazotriazines acting as promising top. II inhibitors and apoptotic inducers with greater selectivity against head and neck tumors: Design, synthesis, and biological assessments. Eur J Med Chem. 2023 Nov 5;259:115661. |
Topoisomerase II inhibitor 14
CAS: 305343-00-4 F: C15H11Cl2N5 W: 332.19
Topoisomerase II inhibitor 14 (compound 2f) is a potent inhibtor of Topoisomerase II, with anticancer activity. Topoisom
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