| Bioactivity | Topoisomerase I inhibitor 3 (Compound ZML-14) is a topoisomerase I inhibitor and can interact with topoisomerase I-DNA complex. Topoisomerase I inhibitor 3 induces HepG2 cell apoptosis and arrests cell cycle at G2/M phase[1]. |
| Invitro | Topoisomerase I inhibitor 3 (Compound ZML-14) shows cytotoxicity with IC50 values of 1.94 ± 0.09, 10.32 ± 0.39, 13.1 ± 0.96, 40.69 ± 5.36, 28.11 ± 2.50, >100 and 37.42 ± 2.05 μM against HepG2, A2780, HeLa, HCT116, SW1990, MCF7 and L-02 cells, respectively[1]. |
| Name | Topoisomerase I inhibitor 3 |
| CAS | 2588211-50-9 |
| Formula | C18H14FNO3 |
| Molar Mass | 311.31 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Topoisomerase I inhibitor 3
CAS: 2588211-50-9 F: C18H14FNO3 W: 311.31
Topoisomerase I inhibitor 3 (Compound ZML-14) is a topoisomerase I inhibitor and can interact with topoisomerase I-DNA c
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