| Bioactivity | Topoisomerase I inhibitor 21 (Compound 3e) is an inhibitor for Topoisomerase I through stabilization of enzyme-DNA complex. Topoisomerase I inhibitor 21 exhibits antiproliferative activity in 39 human cancer cells (JFCR39) with mean GI50 39 nM[1]. |
| Invitro | Topoisomerase I inhibitor 21 抑制癌细胞 MCF7、U251、HCT-166、A549、LOX-IMVI、SK-OV-3、ACHN、MKN28 和 DU145 增殖，EC50 0 --> Topoisomerase I inhibitor 16 相关抗体: |
| Formula | C27H27N3O4 |
| Molar Mass | 457.52 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Sakai K, et al., Design, synthesis, and biological evaluation of novel benzo[6,7]indolo[3,4-c]isoquinolines as anticancer agents with topoisomerase I inhibition. Bioorg Med Chem Lett. 2024 Mar 20:129710. |
Topoisomerase I inhibitor 16
CAS: F: C27H27N3O4 W: 457.52
Topoisomerase I inhibitor 21 (Compound 3e) is an inhibitor for Topoisomerase I through stabilization of enzyme-DNA compl
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