Topoisomerase I inhibitor 12_product_DataBase

Bioactivity	Topoisomerase I inhibitor 12 (compound 12), a Camptothecin (HY-16560)-based derivative, is a potent Topoisomerase I inhibitor. Topoisomerase I inhibitor 12 shows anticancer activity[1].
Invitro	Topoisomerase I inhibitor 12 (compound 12) 对 MDA-MB-231、DU-145、HCT-116、SKOV-3 和 SAOS-2 癌细胞系显示出中等的抗增殖活性 (IC50 值分别为 5.96±0.03、3.81±1.37、3.67±0.21、3.48±1.02 和 3.20±0.21 µM)，以及针对 HOS (骨肉瘤)癌细胞系的有效活性(IC50=1.47 µM)，而对成纤维细胞正常细胞 (BJ1) 的选择性表现出对癌细胞的 2.89 倍选择性 (IC50=4.25 µM)[1]。 0 --> Topoisomerase I inhibitor 12 相关抗体:
Name	Topoisomerase I inhibitor 12
Formula	C23H22N4O3
Molar Mass	402.45
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Ahmed I. Khodair, et al. Camptothecin structure simplification elaborated new imidazo[2,1-b]quinazoline derivative as a human topoisomerase I inhibitor with efficacy against bone cancer cells and colon adenocarcinoma. European Journal of Medicinal Chemistry. 16 December 2023, 116049.

PeptideDB