| Bioactivity | Topo II/HDAC-IN-1 (7d) exhibits excellent dual inhibitory activities against Topo II and HDAC. Topo II/HDAC-IN-1 (8d) induces apoptosis[1]. |
| Invitro | Topo II/HDAC-IN-1 (7d) has the best inhibitory activity against MGC-803 and MCF-7, with IC50 values of 9.59 μM and 13.43 μM respectively[1]. |
| Name | Topo II/HDAC-IN-1 |
| Formula | C15H16N4O3S |
| Molar Mass | 332.38 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Mengmiao Zhao,et al. Design, synthesis and biological evaluation of dual Topo II/HDACinhibitors bearing pyrimido[5,4-b]indole and pyrazolo[3,4-d]pyrimidine motifs. EurJ Med Chem. 2023 Apr 5;252:115303. |