| Bioactivity | Top1 inhibitor 1 (compound 28) is a potent human topoisomerase I (Top1) inhibitor with an IC50 value of 29 nM[1]. |
| Invitro | Top1 inhibitor 1 reveals cytotoxicity in cancerous cells including MCF7 (IC50: 2.74 µM), HeLa (IC50: 2.61 µM), HCT116 (IC50: 2.34 µM), NIH: OVCAR-3 (IC50: 2.35 µM) cells compared to the non-cancerous cells like HEK293 (IC50: 8.34 µM) [1]. |
| Name | Top1 inhibitor 1 |
| CAS | 2302772-05-8 |
| Formula | C24H22N6O2 |
| Molar Mass | 426.47 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |