| Bioactivity | Top/HDAC-IN-2 (45b), a Top and HDAC dual inhibitor, exhibits potent antitumor activities and induces apoptosis[1]. |
| Invitro | Top/HDAC-IN-2 (45b) shows antitumor activities against the HCT116 (IC50 = 0.23 µM), MCF-7 and A549 cells[1].Top/HDAC-IN-2 (45b) (0-5 µM, 24h) arrests the HCT116 cell cycle at the G2 phase in a concentration-dependent manner[1].Top/HDAC-IN-2 (45b) (0-2.5 µM, 24h) induces the apoptosis in HCT116 cell line in a concentration-dependent manner[1].Top/HDAC-IN-2 (45b) (0-5 μM, 24h) inhibits HDAC in living cells[1]. Cell Cycle Analysis[1] Cell Line: |
| Name | Top/HDAC-IN-2 |
| Formula | C30H32N8O4 |
| Molar Mass | 568.63 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Fugui Zhu, et al. Design, Synthesis, and Structure-Activity relationships of Evodiamine-Based topoisomerase (Top)/Histone deacetylase (HDAC) dual inhibitors. Bioorg Chem. 2022 May;122:105702. |