Bioactivity | Tolcapone (Standard) is the analytical standard of Tolcapone. This product is intended for research and analytical applications. Tolcapone (Ro 40-7592) is a selective, orally active and powerful mixed (peripheral and central) COMT inhibitor with an IC50 of 773 nM in the liver. Tolcapone is also a potent inhibitor of α-syn and Aβ42 oligomerization and fibrillogenesis. Tolcapone induces oxidative stress leading to apoptosis and inhibition of tumor growth in neuroblastoma. |
CAS | 134308-13-7 |
Formula | C14H11NO5 |
Molar Mass | 273.24 |
Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |