| Bioactivity | Toladryl is a derivative of Diphenhydramine (HY-B0303), capable of penetrating the blood-brain barrier and possessing oral activity, as well as antihistamine and anticholinergic activities. The anticholinergic activity of Toladryl is approximately one-tenth that of Diphenhydramine (HY-B0303), and its protective effect against lethal doses of histamine in guinea pigs is 2 to 4 times that of Diphenhydramine (HY-B0303). The side effects of Toladryl are fewer and milder than those of Diphenhydramine (HY-B0303), but at higher doses, it may cause central nervous system symptoms such as insomnia, agitation, and disorientation. Toladryl can be used for research in allergic diseases[1]. |
| CAS | 19804-27-4 |
| Formula | C18H23NO |
| Molar Mass | 269.38 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. McGavack T H, et al. Newer antihistaminics: III. Some pharmacologic and therapeutic effects of β-(P-methylbenzhydryloxy)-ethyldimethylamine hydrochloride, a derivative of diphenhydramine hydrochloride[J]. Journal of Allergy, 1950, 21(4): 353-370. |