| Bioactivity | Timolol ((S)-L-714,465; MK 950) hemimaleate is a β-blocker available for both topical and systemic administration. Topical Timolol hemimaleate is primarily used to reduce intraocular pressure with open-angle glaucoma and ocular hypertension. Timolol hemimaleate can also be used for the research of infantile hemangiomas, hypertension, myocardial infarction, migraine prophylaxis, and atrial fibrillation.Timolol also has cardioprotective effect[1][2]. |
| Invitro | Timolol hemimaleate can significantly prevent the increased lipid peroxidation level of the heart from diabetic rats. Timolol hemimaleate can induce a well-balanced ratio between oxidative stress and antioxidant defense system in the diabetic animals, can have an important cardioprotection against diabetes-induced ERS and associated apoptotic effects[3]. 0 --> Timolol hemimaleate 相关抗体: |
| In Vivo | Timolol hemimaleate has a cardioprotective effect via inhibition of ERS response in diabetic rats[3]. Animal Model: |
| Name | Timolol hemimaleate |
| CAS | 33305-95-2 |
| Formula | C13H24N4O3S.1/2C4H4O4 |
| Molar Mass | 374.45 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. James Barnes; Majid Moshirfar. Timolol. [2]. E. Ansari, et al. Treatment of open-angle glaucoma and ocular hypertension with preservative-free tafuprost/timolol fxed-dose combination therapy: 6 case reports and clinical outcomes. BMC Ophthalmol. 2022 Apr 2;22(1):152. [3]. Figen Amber Cicek, et al. Beta-blocker timolol alleviates hyperglycemia-induced cardiac damage via inhibition of endoplasmic reticulum stress. J Bioenerg Biomembr. 2014 Oct;46(5):377-87. |
Timolol hemimaleate
CAS: 33305-95-2 F: C13H24N4O3S.1/2C4H4O4 W: 374.45
Timolol ((S)-L-714,465; MK 950) hemimaleate is a β-blocker available for both topical and systemic administration. Topi
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This product is for research use only, not for human use. We do not sell to patients.