| Bioactivity | Tilapertin is an oral inhibitor of glycine transporter type-1 (GlyT1). |
| Target | GlyT1 |
| In Vivo | Tilapertin is a nanomolar potent, orally bioavailable and selective GlyT1 inhibitor. Oral administration of Tilapertin dose-dependently increases cerebrospinal fluid (CSF) glycine concentration in rats[1]. |
| Name | Tilapertin |
| CAS | 1000690-85-6 |
| Formula | C20H21F3N2O2 |
| Molar Mass | 378.39 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Dunayevich E, et al. Efficacy and safety of the glycine transporter type-1 inhibitor AMG 747 for the treatment of negative symptoms associated with schizophrenia. Schizophr Res. 2017 Apr;182:90-97. |