Tianeptine_product_DataBase

Bioactivity

Tianeptine is a selective facilitator of 5-HT uptake. Tianeptine has no affinity for a wide range of receptors, including 5-HT and dopamine (IC50>10 μM) and has no effect on noradrenalin or dopamine uptake. Tianeptine has antidepressant, anxiolytic, analgesic and neuroprotective activities[1][2][3][4].

CAS

72797-41-2

Formula

C21H25ClN2O4S

Molar Mass

436.95

Appearance

固体

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reference

[1]. Broqua P; Baudrie V; Chaouloff F Differential effects of the novel antidepressant tianeptine on L-5-hydroxytryptophan (5-HTP)-elicited corticosterone release and body weight loss. Eur Neuropsychopharmacol. 1992 Jun;2(2):115-20. [2]. Alamo C, et, al. Tianeptine, an atypical pharmacological approach to depression. Rev Psiquiatr Salud Ment. Jul-Sep 2019;12(3):170-186. [3]. Uzbay IT, et, al. Analgesic effect of tianeptine in mice. Life Sci. 1999;64(15):1313-9. [4]. Plaisant F, et, al. Neuroprotective properties of tianeptine: interactions with cytokines. Neuropharmacology. 2003 May;44(6):801-9.

PeptideDB

Tianeptine

CAS: 72797-41-2 F: C21H25ClN2O4S W: 436.95