| Bioactivity | Thrombin inhibitor 7 is a potent FXIIa inhibitor with IC50 values of 28 nM, >132 µM for FXIIa and FXIa, respectively. Thrombin inhibitor 7 shows low cytotoxicity[1]. |
| Invitro | Thrombin inhibitor 7 (compound 33b) (0-300 µM; 24 h) shows low cytotoxicity in HepG2, A549 cells[1]. Cell Cytotoxicity Assay[1] Cell Line: |
| Name | Thrombin inhibitor 7 |
| CAS | 2866508-00-9 |
| Formula | C26H23N7O2 |
| Molar Mass | 465.51 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Imberg L, et al. Amide-functionalized 1,2,4-Triazol-5-amines as Covalent Inhibitors of Blood Coagulation Factor XIIa and Thrombin. ACS Pharmacol Transl Sci. 2022 Nov 30;5(12):1318-1347. |
Thrombin inhibitor 7
CAS: 2866508-00-9 F: C26H23N7O2 W: 465.51
Thrombin inhibitor 7 is a potent FXIIa inhibitor with IC50 values of 28 nM, >132 µM for FXIIa and FXIa, respectively. T
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