| Bioactivity | ThrRS-IN-3 (compound 36j) is a highly potent threonyl-tRNA synthetase (ThrRS) inhibitor, with an IC50 value of 19 nM and a Kd of 34 nM for Salmonella enterica ThrRS. ThrRS-IN-3 has antibacterial activities[1]. |
| Target | IC50: 19 nM (SeThrRS)Kd: 34 nM (SeThrRS) |
| Name | ThrRS-IN-3 |
| Formula | C31H30Cl2N6O5 |
| Molar Mass | 637.51 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Cai Z, et al. Design, Synthesis, and Proof-of-Concept of Triple-Site Inhibitors against Aminoacyl-tRNA Synthetases. J Med Chem. 2022;65(7):5800-5820. |