| Bioactivity | ThrRS-IN-1 (Compound 30d) is a threonyl-tRNA synthetase (ThrRS) inhibitor with an IC50 of 1.4 µM and a Kd of 1.36 µM against Salmonella enterica ThrRS (SeThrRS). ThrRS-IN-1 simultaneously targets the tRNAThr and L-threonine binding pockets of ThrRS. ThrRS-IN-1 shows potent antibacterial activities[1]. |
| Target | IC50: 1.4 µM (SeThrRS) |
| Name | ThrRS-IN-1 |
| CAS | 2408626-64-0 |
| Formula | C16H18Cl2N4O3 |
| Molar Mass | 385.25 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Junsong Guo, et al. Discovery of novel tRNA-amino acid dual-site inhibitors against threonyl-tRNA synthetase by fragment-based target hopping. Eur J Med Chem. 2020 Feb 1;187:111941. |
ThrRS-IN-1
CAS: 2408626-64-0 F: C16H18Cl2N4O3 W: 385.25
ThrRS-IN-1 (Compound 30d) is a threonyl-tRNA synthetase (ThrRS) inhibitor with an IC50 of 1.4 µM and a Kd of 1.36 µM a
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